Devi Sri Prasad is the story of three close friends Devi (Bhupal Raju) Sri(Dhanraj) and Prasad (Manoj Nandam). A major car accident of a reputed heroine Leela (Pooja Ramachandran) leads to a drastic change in their lives. Who is this Leela? What is her story? What change does she bring in their lives?