The film follows the life of Miggy (John Lloyd Cruz) and Laida (Sarah Geronimo) after their break-up. Miggy is now in a new relationship, while Laida comes out stronger and empowered. Fate brings them together again, with Miggy needing Laida's professional help and Laida confronting Miggy with a new girlfriend. "It Takes a Man and A Woman" is a Filipino romantic comedy from Star Cinema.