Anaganaga Oka Roju is an intense romantic road film with situational humour. Chakri (JD Chakravarthy) & Madhu (Urmila) fall in love with one another but their parents don't get along & keep quarrelling over petty issues. When both their parents don't approve of their relationship they decide to elope and get married. The twist in the tale comes when they get trapped in a murder case.