Invasive Burmese pythons are taking over the Florida Everglades and devouring everything in sight. The only way to stop them is to call in the nation's best swampers: Troy Landry, his son Chase, Bruce Mitchell, and wrangler Zak Bagby.

One week into the hunt for invasive Burmese pythons, the swampers venture into the foreboding Everglades Triangle. Bruce, Zak and Bill hunt near a mysterious abandoned rocket silo.

In the third week of fighting monster serpents, hunters face a terrifying reality: the invasion is bigger than they anticipated.

As the hunters face their final week in the Everglades, Troy and Chase protect a remote community from an aggressive gang of alligators. Then, the swampers join forces to track down a deadly hybrid python.